- Enhances memory and learning.
- Improves resilience and performance under stress.
- Relieves nervous tension and mild anxiety.
BacoMind® – Bacopa monnieri – 45% Bacosides
BacoMind® is a patented extract of Bacopa monnieri, clinically validated to enhance memory and cognition. A powerful nootropic, it is produced via a patented soft-extraction process, BacoMind® is a unique full-spectrum extract, standardized to contain nine synergistic bioactive constituents known as bacosides.
BacoMind® is the most scientifically studied extract of Bacopa monnieri on the market, with 20 published studies demonstrating its nootropic properties and efficacy at improving memory and age-related memory impairment.
While there are many other generic extracts of Bacopa monnieri sold on the market, BacoMind® is the real deal. These inferior extracts found in different popular nootropic formulations often borrow the science from BacoMind® to validate their health claims.
BacoMind® is produced with certified organic Bacopa monnieri, sourced sustainably from carefully selected farms with ideal cultivation conditions. The crops are grown free from pesticide and ochratoxin contamination with ongoing quality control checks throughout its maturation.
Studies have shown multiple pathways through which BacoMind® exerts its nootropic (cognitive enhancing) benefits:
- It inhibits three key enzymes associated with memory and learning (COMT, PEP, and AChE).
- It’s an antagonist of serotonin receptors 5-HT2A and 5-HT6, known to influence neurological pathways associated with cognition.
- It provides neuroprotection via its antioxidant properties.
As an acetylcholinesterase (AChE) enzyme inhibitor, BacoMind® reduces the activity of the primary cholinesterases enzyme, responsible for breaking down the neurotransmitter acetylcholine. Acetylcholine is essential for memory, learning, and attention, and by reducing the activity of AChE, levels of acetylcholine increase, enhancing memory, concentration, and learning ability.
A randomized, double-blind, placebo-controlled study published in the Journal of Pharmacology and Toxicology 2008, looked at the effects of 450 mg/day of BacoMind®, administered to individuals aged 50-75 years with age-associated memory impairment. Individuals supplemented with BacoMind® for a period of 12 weeks were evaluated at the 12 weeks and 24-week marks. Results showed significant improvement (p<0.5) of cognitive functions in the BacoMind® group, in the areas of attention and verbal memory.
In another randomized, double-blind, placebo-controlled study of BacoMind®, published in the Journal of Alternative and Complementary Medicine 2010, looked at the effects of 300 mg/day of BacoMind®, administered to healthy elderly individuals aged 55+ years, over a period of 12 weeks. Again, results showed significantly enhanced memory performance in the BacoMind® group, specifically in verbal learning, memory acquisition, and information retention.
Sharp Mind contains the clinically validated dosage of 300 mg per serve.
Sharp PS® – Phosphatidylserine
Phosphatidylserine often referred to as PS is arguably the most evidence-backed nootropic nutrient for supporting cognition and brain health available on the market. Human clinical studies have demonstrated its ability to improve memory, concentration, learning, and vocabulary skills, across age groups spanning from young adults to seniors experiencing age-associated memory impairment.
Phosphatidylserine is a phospholipid, and it is a major structural component of all cells. Levels of phosphatidylserine in tissue cells vary throughout the body, with the highest concentrations found in the brain. Phosphatidylserine is essential for the healthy formation and function of neuron membranes and myelin. It also supports cell-to-cell communications and synaptic neurotransmission of certain neurotransmitters, including acetylcholine.
Sharp Mind contains 250 mg of the clinically researched Sharp-PS® per serve, a premium branded form of phosphatidylserine. Clinical studies on Sharp-PS® have shown benefit after only six weeks of supplementation, with greater cognitive improvements observed after prolonged use.
ALCAR is a superior and more bioavailable form of L-Carnitine that is more readily able to cross the blood brain barrier and help support brain health and cognitive function.
ALCAR plays an important role in energy metabolism. It helps to fuel the brain by transporting fatty acids into the mitochondria, the cell powerhouses, where they are used to produce ATP cellular energy. It is estimated that the brain consumes at least 20% of the body’s energy, so supporting its energy requirements is vital to maintaining optimal brain function.
ALCAR is also a precursor to the neurotransmitter acetylcholine, associated with memory and learning. ALCAR has been shown to enhance cholinergic neurotransmission, while also providing neuroprotective effects.
Sharp Mind contains 200 mg of ALCAR per serve.
Rhodiola rosea – 3% Salidroside, 1% Rosavins
A popular adaptogen, anxiolytic and nootropic herb, Rhodiola rosea is indigenous to the Arctic and Alpine regions of Russia, Europe, Asia and America. It has traditionally been used to help relieve the symptoms of stress and reduce mental fatigue, while also supporting concentration, mental stamina and mood.
Rhodiola is thought to influence key brain chemicals like serotonin and norepinephrine, and act as a neuroprotective antioxidant.
Sharp Mind contains a clinical 150 mg dose per serve of a premium standardised extract of Rhodiola, containing not less than 3% salidroside and 1% rosavins, the active compounds thought to be responsible for the many health benefits.
Ginkgo biloba – 24% Ginkgo flavonglycosides
Ginkgo is one of the most widely used and researched nootropic brain herbs on the planet. Native to China, Ginkgo is one of the oldest species of trees on earth, with the oldest living tree thought to be 1,400 years old and located in the walls of Gu Guanyin Buddhist Temple, in the Zhongnan Mountain region of China.
Ginkgo supports brain health, mental function and memory recall, through supporting several neurotransmitter systems and neurogenesis, the process in which new brain cells (neurons) are formed in the brain.
Ginkgo also helps maintain healthy blood circulation and cerebral blood flow, crucial to delivering the oxygen and nutrients the brain needs to function at its best.
Sharp Mind contains a clinical 150 mg dose per serve of a premium standardised extract of Ginkgo, containing not less than 24% ginkgo flavonglycosides, the active compound responsible for the ingredients many health benefits.
Paullina cupana (Guarana)
Guarana is a climbing plant native to Brazil. The Amazon tribes have long used guarana seeds, rich in antioxidants, for their therapeutic properties.
Guarana contains about twice the concentration of caffeine found in coffee beans, along with other powerful nootropic compounds including theobromine.
Studies have shown guarana can improve mental focus, learning and memory function.
Sharp Mind contains a clinical 150 mg dose of Guarana, standardised to contain a low dose of caffeine (31.5 mg) and theobromine, associated with improved cognitive function.
Cynara scolymus (Artichoke) – 5% Cynarin
Native to the Mediterranean, Artichoke leaves are a rich source of health promoting antioxidant compounds, including phenolic acids such as cynarin, plus flavonoids such as luteolin, and anthocyanidins.
Artichoke is traditionally used to support gastrointestinal and liver health, but it is also gaining popularity as a nootropic due to its natural ability to inhibit PDE4 in the brain.
Excess PDE4 degrades cyclic adenosine monophosphate (cAMP) in the brain. cAMP is a secondary messenger in neurons and important to neural signaling. It produces proteins needed for neuron and synapse growth, a process known as Long-Term Potentiation (LTP). LTP is widely considered one of the major cellular mechanisms that underlies learning and memory. Memories are effectively formed in the brain by creating LTP.
Inhibition of PDE4 blocks the breakdown of cAMP, thereby up-regulating levels of cAMP within brain cells.
Sharp Mind contains 150 mg per serve of a premium standardised extract of Artichoke, containing not less than 5% caffeic acid derivatives, calculated as cynarin.
When used for this purpose, Artichoke is regularly combined with the below discussed Coleus forskohlii.
Plectranthus barbatus (Coleus forskohlii) – 20% Forskolin
Coleus forskohlii has a long traditional use in Ayurvedic medicine, and belongs to the same family as mint and lavender. It contains a unique compound called forskolin, which is the only supplement known to naturally increase levels of cyclic adenosine monophosphate (cAMP), essential for neuron and synapse growth (LTP).
Sharp Mind contains 60 mg per serve of a premium standardised extract of Coleus forskohlii, containing not less than 2o% forskolin.