- Enhances memory and learning.
- Improves resilience and performance under stress.
- Relieves nervous tension and mild anxiety.
BacoMind® – Bacopa monnieri (organic)
BacoMind® is a patented extract of Bacopa monnieri, clinically validated to enhance memory and cognition. A powerful nootropic, it is produced via a patented soft-extraction process, BacoMind® is a unique full-spectrum extract, standardized to contain nine synergistic bioactive constituents known as bacosides.
BacoMind® is the most scientifically studied extract of Bacopa monnieri on the market, with 20 published studies demonstrating its nootropic properties and efficacy at improving memory and age-related memory impairment.
While there are many other generic extracts of Bacopa monnieri sold on the market, BacoMind® is the real deal. These inferior extracts found in different popular nootropic formulations often borrow the science from BacoMind® to validate their health claims.
BacoMind® is produced with certified organic Bacopa monnieri, sourced sustainably from carefully selected farms with ideal cultivation conditions. The crops are grown free from pesticide and ochratoxin contamination with ongoing quality control checks throughout its maturation.
Studies have shown multiple pathways through which BacoMind® exerts its nootropic (cognitive enhancing) benefits:
- It inhibits three key enzymes associated with memory and learning (COMT, PEP, and AChE).
- It’s an antagonist of serotonin receptors 5-HT2A and 5-HT6, known to influence neurological pathways associated with cognition.
- It provides neuroprotection via its antioxidant properties.
As an acetylcholinesterase (AChE) enzyme inhibitor, BacoMind® reduces the activity of the primary cholinesterases enzyme, responsible for breaking down the neurotransmitter acetylcholine. Acetylcholine is essential for memory, learning, and attention, and by reducing the activity of AChE, levels of acetylcholine increase, enhancing memory, concentration, and learning ability.
A randomized, double-blind, placebo-controlled study published in the Journal of Pharmacology and Toxicology 2008, looked at the effects of 450 mg/day of BacoMind®, administered to individuals aged 50-75 years with age-associated memory impairment. Individuals supplemented with BacoMind® for a period of 12 weeks were evaluated at the 12 weeks and 24-week marks. Results showed significant improvement (p<0.5) of cognitive functions in the BacoMind® group, in the areas of attention and verbal memory.
In another randomized, double-blind, placebo-controlled study of BacoMind®, published in the Journal of Alternative and Complementary Medicine 2010, looked at the effects of 300 mg/day of BacoMind®, administered to healthy elderly individuals aged 55+ years, over a period of 12 weeks. Again, results showed significantly enhanced memory performance in the BacoMind® group, specifically in verbal learning, memory acquisition, and information retention.
Our Sharp Mind product contains the highest clinically validated dosage of 450 mg per day.
KSM-66® – Ashwagandha (organic)
KSM-66® is a full-spectrum extract of Ashwagandha, supported by extensive research and randomized, double-blind, placebo-controlled human clinical trials. KSM-66® has proven clinical efficacy in the areas of memory and cognition, stress relief, muscle strength, endurance, sexual health, weight management, and thyroid health.
The certified organic KSM-66® extract is produced by Ixoreal using Ashwagandha cultivated on their farms and extracted using a unique proprietary green-chemistry, free of alcohol or chemical solvents. KSM-66® has the highest concentration of active constituents of all Ashwagandha root-only extracts available on the market today.
Ashwagandha (Withania somnifera) is the flagship herb of the traditional Ayurveda system of medicine from India. An adaptogenic herb, Ashwagandha helps the body adapt to stressful conditions, administering its effects on both physical and mental planes.
KSM-66® has been clinically proven to enhance memory and cognitive function, and reduce stress, lower cortisol levels, and relieve mild anxiety.
Sharp Mind contains KSM-66® at the highest clinically validated dose and with directions of use that match the dosage schedule of the clinical trials.
Sharp PS® – Phosphatidylserine
Phosphatidylserine often referred to as PS is arguably the most evidence-backed nootropic nutrient for supporting cognition and brain health available on the market. Human clinical studies have demonstrated its ability to improve memory, concentration, learning, and vocabulary skills, across age groups spanning from young adults to seniors experiencing age-associated memory impairment.
Phosphatidylserine is a phospholipid, and it is a major structural component of all cells. Levels of phosphatidylserine in tissue cells vary throughout the body, with the highest concentrations found in the brain. Phosphatidylserine is essential for the healthy formation and function of neuron membranes and myelin. It also supports cell-to-cell communications and synaptic neurotransmission of certain neurotransmitters, including acetylcholine.
Sharp Mind uses 120 mg of clinically researched Sharp-PS®, a premium branded form of phosphatidylserine. Clinical studies on Sharp-PS® have shown benefit after only six weeks of supplementation, with greater cognitive improvements observed after prolonged use.
Quatrefolic® – Folate
Quatrefolic® is the most advanced form of folate supplementation available on the market. It contains levomefolate glucosamine, a biologically active form of folate, known as 5-methyltetrahydrofolate (5-MTFH). Quatrefolic® offers you increased stability and bioavailability over dietary folate, folic acid, and bio-active calcium salt forms of 5-MTFH such as Metafolin.
Folate is involved in the production of key neurotransmitters in the brain, and low concentrations are associated with mood disorders. A deficiency in folate is a recognized factor in cognitive decline with research showing a prevalence of deficiency in older populations.
Folate is vital for DNA synthesis, red blood cell production, cell division, and the remethylation of homocysteine. Homocysteine is a biomarker associated with cardiovascular health and certain neurodegenerative disorders.
Vitamin B12 (bio-activated Methylcobalamin)
Vitamin B12 deficiency is a recognized factor in cognitive decline, with low blood serum levels associated with a higher risk of certain neurodegenerative and mental disorders. Sharp Mind contains the bio-activated form of vitamin B12 known as methylcobalamin, allowing for immediate utilization in the body. This form bypasses any potential impact from a genetic polymorphism such as the MTHFR genetic defect, which reduces the ability to methylate this vitamin naturally.
Vitamin B12 plays a crucial role in the neurological structure and function, DNA synthesis, red blood cell formation, healthy energy metabolism, and in the remethylation of homocysteine.
Also known as thiamine, Vitamin B1 is an essential co-factor in many metabolic processes and is involved in metabolizing the food you eat into ATP cellular energy. It is a component of the enzyme Thiamine pyrophosphate (TPP). TPP is crucial for nerve cell function, neurotransmission, and nerve conduction. Vitamin B1 is also involved in the synthesis of the neurotransmitter acetylcholine.
Also known as pantothenic acid, Vitamin B5 is required by the body to synthesize coenzyme-A (CoA), vital to many life-sustaining biochemical processes, including the production of ATP cellular energy. CoA is necessary for the synthesis of fatty acids, cholesterol, and proper adrenal function.
CoA is essential to the conversion process of choline into neurotransmitter acetylcholine, associated with learning, memory, and focus.
A conditionally essential amino acid, Tyrosine is produced in the body by the essential amino acid Phenylalanine. In addition to being a precursor to thyroid hormones, it is also used to synthesize the catecholamine class of neurotransmitters, some of which play a crucial role in the brain’s reward system and is associated with movement, motivation, mood, memory, and maintaining a sharp mind.